granularchive/data.json

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      "source": "8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.",
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      "source": "New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase",
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    { "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes", "target": "076-538-237-089-675", "value": 2 },
    { "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes", "target": "051-324-518-696-462", "value": 2 },
    { "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes", "target": "198-017-973-913-570", "value": 2 },
    { "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes", "target": "156-653-831-632-101", "value": 2 },
    { "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes", "target": "178-739-712-688-618", "value": 2 },
    { "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes", "target": "048-634-530-447-798", "value": 2 },
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    { "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.", "target": "165-291-395-706-725", "value": 2 },
    { "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.", "target": "047-113-007-956-15X", "value": 2 },
    { "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.", "target": "089-019-916-582-397", "value": 2 },
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      "source": "Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle",
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    { "source": "Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation", "target": "156-286-485-464-499", "value": 2 },
    { "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65", "target": "001-353-214-346-040", "value": 2 },
    { "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65", "target": "118-479-143-842-720", "value": 2 },
    { "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65", "target": "007-641-959-106-118", "value": 2 },
    { "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65", "target": "189-040-066-278-226", "value": 2 },
    { "source": "Substrate recognition by the cell surface palmitoyl transferase DHHC5.", "target": "106-594-488-484-12X", "value": 2 },
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    { "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples", "target": "113-229-447-433-64X", "value": 2 },
    { "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples", "target": "077-771-399-719-227", "value": 2 },
    { "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples", "target": "183-966-651-664-305", "value": 2 },
    { "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples", "target": "013-467-292-050-692", "value": 2 },
    { "source": "Structure-activity relationship studies of pyrrolone antimalarial agents", "target": "079-314-054-163-947", "value": 2 },
    { "source": "Structure-activity relationship studies of pyrrolone antimalarial agents", "target": "110-082-309-221-187", "value": 2 },
    { "source": "The Concise Guide to Pharmacology 2013/14.: The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors", "target": "128-382-566-327-896", "value": 2 },
    { "source": "The Concise Guide to Pharmacology 2013/14.: The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors", "target": "143-543-676-408-839", "value": 2 },
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    { "source": "Metabolism of inflammation limited by AMPK and pseudo-starvation", "target": "026-638-223-054-804", "value": 2 },
    { "source": "Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration", "target": "048-208-660-423-215", "value": 2 },
    { "source": "The anti-inflammatory compound BAY 11-7082 is a potent inhibitor of Protein Tyrosine Phosphatases", "target": "159-658-602-048-982", "value": 2 },
    { "source": "BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm", "target": "077-811-145-153-079", "value": 2 },
    { "source": "BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm", "target": "170-781-236-728-970", "value": 2 },
    { "source": "BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm", "target": "144-284-594-583-951", "value": 2 },
    { "source": "Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase", "target": "139-409-891-293-77X", "value": 2 },
    { "source": "Discovery and structure-activity relationships of pyrrolone antimalarials", "target": "110-082-309-221-187", "value": 2 },
    { "source": "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments", "target": "081-017-751-048-013", "value": 2 },
    { "source": "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments", "target": "114-963-910-586-828", "value": 2 },
    { "source": "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments", "target": "162-513-842-046-362", "value": 2 },
    { "source": "Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies", "target": "188-803-921-043-695", "value": 2 },
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      "source": "From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules",
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      "source": "From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules",
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    { "source": "HIF-independent role of prolyl hydroxylases in the cellular response to amino acids", "target": "106-530-060-683-82X", "value": 2 },
    { "source": "HIF-independent role of prolyl hydroxylases in the cellular response to amino acids", "target": "133-935-409-400-672", "value": 2 },
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    { "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones", "target": "051-324-518-696-462", "value": 2 },
    { "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones", "target": "161-487-188-181-03X", "value": 2 },
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    { "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones", "target": "076-538-237-089-675", "value": 2 },
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      "source": "A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways",
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    { "source": "X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor", "target": "051-324-518-696-462", "value": 2 },
    { "source": "The endosome-lysosome pathway and information generation in the immune system.", "target": "190-195-697-065-907", "value": 2 },
    { "source": "The endosome-lysosome pathway and information generation in the immune system.", "target": "031-461-589-086-771", "value": 2 },
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    { "source": "The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase", "target": "097-019-537-894-104", "value": 2 },
    { "source": "The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase", "target": "170-696-774-214-700", "value": 2 },
    { "source": "Application of a novel highly sensitive activity-based probe for detection of cathepsin G", "target": "084-807-525-209-072", "value": 2 },
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      "source": "PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65",
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      "source": "PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65",
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      "source": "PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65",
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    { "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors", "target": "075-397-286-033-085", "value": 2 },
    { "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors", "target": "028-992-308-265-357", "value": 2 },
    { "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors", "target": "044-207-676-689-405", "value": 2 },
    { "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors", "target": "030-350-713-791-200", "value": 2 },
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      "source": "Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.",
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      "source": "Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.",
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      "source": "Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics",
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      "source": "Acinetobacter baumannii FolD ligand complexes – potent inhibitors of folate metabolism and a re‐evaluation of the structure of LY374571",
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    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "000-150-893-948-804", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "027-437-502-794-894", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "074-789-039-135-70X", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "063-617-165-524-327", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "019-872-586-012-269", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "103-648-347-913-447", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "007-245-406-573-328", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "027-437-502-794-894", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "008-337-248-044-723", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "197-071-041-313-103", "value": 2 },
    { "source": "Aurora kinase inhibitors: Progress towards the clinic", "target": "098-538-513-984-747", "value": 2 },
    { "source": "The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes", "target": "019-125-805-246-964", "value": 2 },
    { "source": "The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes", "target": "172-064-016-145-117", "value": 2 },
    { "source": "The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes", "target": "007-417-942-335-284", "value": 2 },
    { "source": "Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition", "target": "005-947-025-410-764", "value": 2 },
    { "source": "Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition", "target": "116-404-026-640-450", "value": 2 },
    { "source": "Discovery of potent and selective covalent inhibitors of JNK", "target": "090-437-295-781-023", "value": 2 },
    { "source": "Discovery of potent and selective covalent inhibitors of JNK", "target": "197-158-559-918-854", "value": 2 },
    { "source": "Discovery of potent and selective covalent inhibitors of JNK", "target": "076-225-263-850-117", "value": 2 },
    { "source": "Discovery of potent and selective covalent inhibitors of JNK", "target": "049-199-509-181-561", "value": 2 },
    { "source": "Discovery of potent and selective covalent inhibitors of JNK", "target": "179-045-041-176-506", "value": 2 },
    { "source": "Discovery of potent and selective covalent inhibitors of JNK", "target": "004-301-778-674-378", "value": 2 },
    { "source": "Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin", "target": "111-313-231-732-367", "value": 2 },
    { "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis", "target": "092-197-031-561-353", "value": 2 },
    { "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis", "target": "192-019-786-423-841", "value": 2 },
    { "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis", "target": "192-019-786-423-841", "value": 2 },
    { "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis", "target": "076-608-180-638-59X", "value": 2 },
    { "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis", "target": "175-263-797-963-040", "value": 2 },
    { "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis", "target": "092-197-031-561-353", "value": 2 },
    { "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.", "target": "141-694-167-791-759", "value": 2 },
    { "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.", "target": "081-203-444-563-604", "value": 2 },
    { "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.", "target": "125-348-249-762-351", "value": 2 },
    { "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.", "target": "125-850-986-196-787", "value": 2 },
    { "source": "Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction", "target": "119-397-162-706-860", "value": 2 },
    { "source": "Small molecules that bind the Mdm2 RING stabilize and activate p53", "target": "133-023-408-974-285", "value": 2 },
    { "source": "Small molecules that bind the Mdm2 RING stabilize and activate p53", "target": "039-847-299-166-952", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "076-641-402-312-988", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "102-485-198-725-150", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "168-829-456-947-639", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "098-813-369-162-741", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "023-180-369-416-862", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "189-473-046-734-005", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "019-633-684-883-828", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "174-501-376-407-235", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "129-062-448-949-030", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "162-916-741-322-002", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "080-026-305-809-343", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "016-698-167-713-829", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "091-325-080-234-401", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "032-206-614-235-635", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "143-271-017-351-983", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "169-312-245-869-778", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "089-818-979-077-305", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "187-517-157-601-239", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "111-583-988-147-450", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "058-026-435-099-506", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "153-651-762-444-327", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "159-766-711-047-610", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "058-933-099-316-100", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "023-452-662-674-373", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "047-432-030-246-04X", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "139-008-712-602-518", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "137-720-748-139-162", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "192-136-893-476-749", "value": 2 },
    { "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice", "target": "172-890-893-515-719", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "104-472-615-006-481", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "097-374-332-908-898", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "034-416-075-094-770", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "127-642-274-375-054", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "036-708-909-192-156", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "193-863-590-855-263", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "150-028-859-997-047", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "034-416-075-094-770", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "097-374-332-908-898", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "104-472-615-006-481", "value": 2 },
    { "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern", "target": "132-394-716-226-832", "value": 2 },
    { "source": "Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes", "target": "168-483-508-794-377", "value": 2 },
    { "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.", "target": "131-238-819-455-784", "value": 2 },
    { "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.", "target": "155-402-461-387-483", "value": 2 },
    { "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.", "target": "040-389-070-176-191", "value": 2 },
    { "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.", "target": "076-478-479-475-120", "value": 2 },
    { "source": "A multifunctional protease inhibitor to regulate endolysosomal function.", "target": "031-461-589-086-771", "value": 2 },
    { "source": "A multifunctional protease inhibitor to regulate endolysosomal function.", "target": "190-195-697-065-907", "value": 2 },
    {
      "source": "Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogues as Inhibitors of the Annexin A2−S100A10 Protein Interaction",
      "target": "034-190-802-321-708",
      "value": 2
    },
    { "source": "4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.", "target": "130-316-719-983-242", "value": 2 },
    { "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors", "target": "076-478-479-475-120", "value": 2 },
    { "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors", "target": "040-389-070-176-191", "value": 2 },
    { "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors", "target": "036-668-261-470-040", "value": 2 },
    { "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors", "target": "183-767-289-461-131", "value": 2 },
    { "source": "Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1", "target": "107-556-164-321-147", "value": 2 },
    { "source": "The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation.", "target": "106-594-488-484-12X", "value": 2 },
    { "source": "SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a keap1-independent manner", "target": "066-190-726-252-149", "value": 2 },
    {
      "source": "Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone",
      "target": "140-900-012-438-14X",
      "value": 2
    },
    { "source": "Absolute SILAC-Compatible Expression Strain Allows Sumo-2 Copy Number Determination in Clinical Samples", "target": "058-438-690-312-096", "value": 2 },
    { "source": "Absolute SILAC-Compatible Expression Strain Allows Sumo-2 Copy Number Determination in Clinical Samples", "target": "004-889-112-130-518", "value": 2 },
    { "source": "Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.", "target": "193-040-307-473-220", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "188-718-220-131-362", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "087-577-350-425-176", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "191-670-060-004-126", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "188-803-921-043-695", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "041-699-843-843-567", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "180-366-233-781-99X", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "156-653-831-632-101", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "051-324-518-696-462", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "161-487-188-181-03X", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "167-851-091-520-257", "value": 2 },
    { "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2", "target": "122-739-962-072-793", "value": 2 },
    { "source": "ATP site-directed inhibitors of protein kinase CK2: an update.", "target": "109-274-898-147-341", "value": 2 },
    { "source": "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3", "target": "124-179-501-005-870", "value": 2 },
    { "source": "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3", "target": "008-694-981-426-172", "value": 2 },
    { "source": "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3", "target": "109-611-546-954-080", "value": 2 },
    { "source": "Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.", "target": "004-378-254-734-355", "value": 2 },
    { "source": "Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.", "target": "133-997-520-845-569", "value": 2 },
    { "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.", "target": "115-381-943-359-61X", "value": 2 },
    { "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.", "target": "022-078-711-389-998", "value": 2 },
    { "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.", "target": "132-854-391-972-865", "value": 2 },
    { "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.", "target": "171-143-110-884-468", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "003-946-199-636-328", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "009-649-401-227-606", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "170-042-571-881-121", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "033-301-273-471-462", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "040-826-560-477-838", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "048-208-660-423-215", "value": 2 },
    { "source": "The cytoprotective role of the Keap1–Nrf2 pathway", "target": "135-293-472-746-415", "value": 2 },
    { "source": "Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors", "target": "153-999-081-812-523", "value": 2 },
    { "source": "Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors", "target": "000-498-778-953-787", "value": 2 },
    { "source": "Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors", "target": "085-065-777-135-758", "value": 2 },
    {
      "source": "Analgesic omega-Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels (vol 77, pg 139, 2010)",
      "target": "152-366-692-522-975",
      "value": 2
    },
    {
      "source": "Analgesic omega-Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels (vol 77, pg 139, 2010)",
      "target": "167-869-142-610-582",
      "value": 2
    },
    { "source": "NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration", "target": "191-676-336-200-724", "value": 2 },
    { "source": "Development of 18F-fluorinatable dendrons and their application to cancer cell targeting", "target": "056-387-403-639-935", "value": 2 },
    { "source": "The specificities of small molecule inhibitors of the TGFß and BMP pathways", "target": "066-841-401-628-941", "value": 2 },
    { "source": "The specificities of small molecule inhibitors of the TGFß and BMP pathways", "target": "069-503-782-573-055", "value": 2 },
    { "source": "The specificities of small molecule inhibitors of the TGFß and BMP pathways", "target": "028-137-796-142-577", "value": 2 },
    { "source": "Catalysis by the nucleolytic ribozymes", "target": "197-678-301-596-236", "value": 2 },
    { "source": "Catalysis by the nucleolytic ribozymes", "target": "147-466-934-435-143", "value": 2 },
    { "source": "Catalysis by the nucleolytic ribozymes", "target": "114-647-123-099-321", "value": 2 },
    { "source": "Catalysis by the nucleolytic ribozymes", "target": "058-829-130-504-901", "value": 2 },
    { "source": "Catalysis by the nucleolytic ribozymes", "target": "169-953-034-717-264", "value": 2 },
    { "source": "Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1", "target": "028-012-588-449-727", "value": 2 },
    { "source": "Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1", "target": "038-839-140-589-623", "value": 2 },
    { "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases", "target": "194-924-906-201-593", "value": 2 },
    { "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases", "target": "195-611-964-620-410", "value": 2 },
    { "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases", "target": "025-014-524-538-421", "value": 2 },
    { "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases", "target": "025-014-524-538-421", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "120-667-268-642-909", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "163-117-320-460-138", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "191-290-593-697-506", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "118-339-847-530-982", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "073-318-370-112-877", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "113-828-920-381-078", "value": 2 },
    { "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function", "target": "048-983-957-537-421", "value": 2 },
    { "source": "Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488", "target": "073-531-962-083-670", "value": 2 }
  ]
}